RAF Typhoon FGR4s have conducted a mission with French aircraft in a coordinated attack against an hidden munitions depot in Syria operated by the Daesh militant organization, according to the UK's MoD.
The facility, located using intelligence, was thought to be housing weapons and explosive materials, the statement said, and was located in hills just to the north of the historic site of Palmyra in Syria's central region.
"Our aircraft utilized Paveway IV guided bombs to strike a several access tunnels providing entry to the facility... early reports are that the objective was successfully hit," officials stated.
There was no evidence of any civilian casualties in the strike late on Saturday and every plane involved made a safe return, the ministry further stated.
The Typhoon FGR4s were supported by a Voyager tanker plane.
Daesh - referred to as the so-called Islamic State - enforced jihadist rule over parts of Iraq and Syria prior to its 2019 collapse.
"This action demonstrates our UK leadership, and resolve to work closely with our partners, to eradicate any resurgence of Daesh and their dangerous and violent ideologies in the area," UK Defence Secretary John Healey said.
UK warplanes have carried out surveillance missions over Syrian airspace to "deter any efforts to regroup" of IS subsequent to its military defeat at the battle of Baghuz in 2019, the ministry said.
"I want to thank the personnel of the UK armed forces participating in this strike for their expertise and their courage," Healey commented. "They were among thousands of British troops on duty over Christmas and New Year. This action, to take out militants who endanger our safety, shows how British military are always on standby, throughout the year, protecting the UK within its borders and strong abroad."
During December, the American forces executed what it described as a "major assault" against IS targets in the country, after an attack claimed the lives of two US troops and a local interpreter in the Palmyra area.
The United Nations reports Islamic State still maintains an estimated 5,000 to 7,000 combatants in Iraq and Syria.